Coming off a productive Week 5, George Kittle is set for another busy evening as he faces a favorable matchup against a ...

The NFL's Week 6 will kick off with a "Thursday Night Football" matchup between two teams coming off head-scratching losses: ...

Analyzing Thursday’s San Francisco 49ers at Seattle Seahawks odds and lines, with expert NFL picks and predictions.

Mike Macdonald shut down the San Francisco 49ers last season, and now looks to do the same with the Seattle Seahawks.

The San Francisco 49ers' rushing attack presents a big test for the Seattle Seahawks and their struggling defense.

With Seattle's defense dealing with a slew of injuries, Brock Purdy should have little difficulty connecting with his healthy ...

Samuel has accumulated 19.2 fantasy points (6.4 per game) during his past three games. He has 179 yards receiving, on 12 ...

In his best game of the season, Brock Purdy finished with 25.8 fantasy points -- 22-of-30 (73.3%), 292 yards, 3 TDs, 0 INTs; ...

The San Francisco 49ers will face off against the Seattle Seahawks in Week 6 of the NFL season on Thursday. This prediction ...

The Seattle Seahawks will host the divisional matchup with the 49ers for Thursday Night Football.  Both teams will be looking to rebound from Week 5 upset losse ...

The San Francisco 49ers are not where they hoped to be five games into the season. Sitting at 2-3 and with two divisional ...

NFC West rivalry finds 49ers’ struggling red zone offense facing a Seahawks defense beaten for 71 points in two straight ...